Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy.

ABSTRACT:

Background

Despite the significant contributions of monocytes to HIV persistence, the HIV-monocyte interaction remains elusive. For patients on antiretroviral therapy, previous studies observed a virological suppression rate of >70% and suggested complete viral suppression as the primary goal. Although some studies have reported genetic dysregulations associated with HIV disease progression, research on ex vivo-derived monocytic transcriptomes from HIV+ patients with differential responses to therapy is limited. This study investigated the monocytic transcriptome distinctions between patients with sustained virus suppression and those with virological failure during highly active antiretroviral therapy (HAART).

Methods

Genome-wide transcriptomes of primary monocytes from fiv

SUBMITTER: Wu JQ 

PROVIDER: S-EPMC3877975 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature