ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women.

ABSTRACT: BACKGROUND:African-Americans are more insulin-resistant than whites but have lower triglyceride (TG) concentrations. The metabolic basis for this is unknown. Our goal was to determine in a cross-sectional study the effect of insulin resistance, visceral adipose tissue (VAT) and the apolipoproteins, B, C-III and E, on race differences in TG content of very low density lipoproteins (VLDL). METHODS:The participants were 31 women (16 African-American, 15 white) of similar age (37?±?9 vs. 38?±?11y (mean?±?SD), P =?0.72) and BMI (32.4?±?7.2 vs. 29.3?±?6.0 kg/m2, P =?0.21). A standard diet (33% fat, 52% carbohydrate, 15% protein) was given for 7 days followed by a test meal (40% fat, 40% carbohydrate, 20% protein) on Day 8. Insulin sensitivity index (SI) was calculated from the minimal model. VAT was measured at L2-3. The influence of race, SI, VAT and apolipoproteins on the TG content of VLDL was determined by random effects models (REM). RESULTS:African-Americans were more insulin-resistant (SI: 3.6?±?1.3 vs. 5.6?±?2.6 mU/L-1.min-1, P

SUBMITTER: Sumner AE 

PROVIDER: S-EPMC3878037 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature