Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.
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ABSTRACT:
SUBMITTER: Kang HS
PROVIDER: S-EPMC3878715 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes.
Kang Hahk-Soo HS Brady Sean F SF
Angewandte Chemie (International ed. in English) 20130903 42
Sequence-tag-guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA-derived arm cluster encodes arimetamycin A, an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug-resistant (MDR) cancer cells. ...[more]
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