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Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.


ABSTRACT: OBJECTIVE:The chromosomal region, 15q13-q14, including the ?7 nicotinic acetylcholine receptor gene, CHRNA7, is a replicated region for schizophrenia. This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7. METHODS:Family-based and case-control association studies were performed on Caucasian-non-Hispanic and African-American individuals from 120 families as well as 468 individual patients with schizophrenia and 144 well-characterized controls. Single-nucleotide polymorphism (SNP) markers were genotyped, and association analyses carried out for the outcomes of schizophrenia, smoking, and smoking in schizophrenia. RESULTS:Three genes were associated with schizophrenia in both ethnic populations: TRPM1, KLF13, and RYR3. Two SNPs in CHRNA7 were associated with schizophrenia in African-Americans, and a second SNP in CHRNA7 was significant for an association with smoking and smoking in schizophrenia in Caucasians. CONCLUSION:Results of these studies support association of the 15q13-q14 region with schizophrenia. The broad positive association suggests that more than one 15q gene may be contributing to the disorder, either in combination or through a regulatory mechanism.

SUBMITTER: Stephens SH 

PROVIDER: S-EPMC3878876 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.

Stephens Sarah H SH   Franks Alexis A   Berger Ralph R   Palionyte Milda M   Fingerlin Tasha E TE   Wagner Brandie B   Logel Judith J   Olincy Ann A   Ross Randal G RG   Freedman Robert R   Leonard Sherry S  

Psychiatric genetics 20120201 1


<h4>Objective</h4>The chromosomal region, 15q13-q14, including the α7 nicotinic acetylcholine receptor gene, CHRNA7, is a replicated region for schizophrenia. This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7.<h4>Methods</h4>Family-based and case-control association studies were performed on Caucasian-non-Hispanic and African-American individuals from 120 families as well as 468 individual patients with schizophrenia and 144 well-characterized con  ...[more]

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