Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production.

ABSTRACT:

Background

Industrial fermentations can generally be described as dynamic biotransformation processes in which microorganisms convert energy rich substrates into a desired product. The knowledge of active physiological pathways, reflected by corresponding gene activities, allows the identification of beneficial or disadvantageous performances of the microbial host. Whole transcriptome RNA-Seq is a powerful tool to accomplish in-depth quantification of these gene activities, since the low background noise and the absence of an upper limit of quantification allow the detection of transcripts with high dynamic ranges. Such data enable the identification of potential bottlenecks and futile energetic cycles, which in turn can lead to targets for rational approaches to productivity impro

SUBMITTER: Wiegand S 

PROVIDER: S-EPMC3878961 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature