Ontology highlight
ABSTRACT:
SUBMITTER: Bewley MC
PROVIDER: S-EPMC3879131 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Bewley Maria C MC Tash Brian R BR Tian Fang F Flanagan John M JM
Tissue barriers 20130101 1
Tight junctions (TJs) are protein complexes comprised of claudins, which anchor them in the membrane and numerous cytosolic scaffolding proteins including MAGI, MUPP1, cingulin and members of the Zonula Occludens (ZO) family. Originally, their main function was thought to be as a paracellular barrier. More recently, however, additional roles in signal transduction, differentiation and proliferation have been reported. Dysregulation is associated with a wide range of disease states, including dia ...[more]