Ontology highlight
ABSTRACT:
SUBMITTER: Warner JF
PROVIDER: S-EPMC3879447 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Warner Jacob F JF McCarthy Ali M AM Morris Robert L RL McClay David R DR
Molecular biology and evolution 20131011 1
A relatively small number of signaling pathways govern the early patterning processes of metazoan development. The architectural changes over time to these signaling pathways offer unique insights into their evolution. In the case of Hedgehog (Hh) signaling, two very divergent mechanisms of pathway transduction have evolved. In vertebrates, signaling relies on trafficking of Hh pathway components to nonmotile specialized primary cilia. In contrast, protostomes do not use cilia of any kind for Hh ...[more]