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Hyponatremia and anti-diuretic hormone in Legionnaires' disease.

ABSTRACT: Medical textbooks often list Legionnaires' disease as a differential diagnosis of the syndrome of inappropriate secretion of anti-diuretic hormone (ADH) (SIADH), but evidence supporting this association is largely lacking. We tested the hypothesis whether hyponatremia in patients with Legionnaires' disease would be caused by increased CT-ProVasopressin.We measured CT-ProVasopressin and sodium levels in a prospective cohort of 873 pneumonia patients from a previous multicentre study with 27 patients having positive antigen tests for Legionella pneumophila.Patients with Legionnaires' disease more frequently had low sodium levels (Na?

SUBMITTER: Schuetz P

PROVIDER: S-EPMC3880094 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Hyponatremia and anti-diuretic hormone in Legionnaires' disease.

Schuetz Philipp P Haubitz Sebastian S Christ-Crain Mirjam M Albrich Werner C WC Zimmerli Werner W Mueller Beat B

BMC infectious diseases 20131211

<h4>Background</h4>Medical textbooks often list Legionnaires' disease as a differential diagnosis of the syndrome of inappropriate secretion of anti-diuretic hormone (ADH) (SIADH), but evidence supporting this association is largely lacking. We tested the hypothesis whether hyponatremia in patients with Legionnaires' disease would be caused by increased CT-ProVasopressin.<h4>Methods</h4>We measured CT-ProVasopressin and sodium levels in a prospective cohort of 873 pneumonia patients from a previ ...[more]

PMID: 24330484

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