Ontology highlight
ABSTRACT:
SUBMITTER: Jung JP
PROVIDER: S-EPMC3880157 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Jung Jangwook P JP Sprangers Anthony J AJ Byce John R JR Su Jing J Squirrell Jayne M JM Messersmith Phillip B PB Eliceiri Kevin W KW Ogle Brenda M BM
Biomacromolecules 20130820 9
Limiting the precise study of the biochemical impact of whole molecule extracellular matrix (ECM) proteins on stem cell differentiation is the lack of 3D in vitro models that can accommodate many different types of ECM. Here we sought to generate such a system while maintaining consistent mechanical properties and supporting stem cell survival. To this end, we used native chemical ligation to cross-link poly(ethylene glycol) macromonomers under mild conditions while entrapping ECM proteins (term ...[more]