Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3881041 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure.
Wang Lei L Wang Jue J Wang Yong Y Fu Qiang Q Lei Yong-Hua YH Nie Zhi-Yong ZY Qiu Jianxin J Bao Ting-Yi TY
Experimental and therapeutic medicine 20131115 2
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have pivotal functions in extracellular matrix turnover and are involved in chronic kidney diseases. However, the exact functions of MMPs in chronic renal failure (CRF) have yet to be demonstrated. The aim of the present study was to examine the effects of MMP-9 on CRF. An adenine-induced model of CRF was generated in rabbits. Following the injection of MMP-9 into the renal arteries of the rabbits, significant i ...[more]
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