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Matrix metalloproteinase-9 in chronic lymphocytic leukemia

ABSTRACT: Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of malignant CD5+ B lymphocytes (CLL cells) in the peripheral blood, and their progressive infiltration in lymphoid organs. MMP-9 plays an important role in cell migration and survival, contributes to CLL pathogenesis by proteolytic and non-proteolytic mechanisms and may constitutive a therapeutic target. We used Affimetrix microarray technology to characterize the global gene expression profile of chronic lymphocytic leukemia (CLL) cells upon MMP-9 transfection. The aim was to establish whether MMP-9 regulates gene expression and to identify new therapeutic targets in CLL.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78174 | GEO | 2016/03/21

SECONDARY ACCESSION(S): PRJNA312827

REPOSITORIES: GEO

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