Ontology highlight
ABSTRACT:
SUBMITTER: Huang LH
PROVIDER: S-EPMC3882116 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Huang Li-Hao LH Gui Jingang J Artinger Erika E Craig Ruth R Berwin Brent L BL Ernst Patricia A PA Chang Catherine C Y CC Chang Ta-Yuan TY
Arteriosclerosis, thrombosis, and vascular biology 20130711 9
<h4>Objective</h4>To investigate the role of acyl-CoA:cholesterol acyltransferase 1 (ACAT1) in hematopoiesis.<h4>Approach and results</h4>ACAT1 converts cellular cholesterol to cholesteryl esters for storage in multiple cell types and is a potential drug target for human diseases. In mouse models for atherosclerosis, global Acat1 knockout causes increased lesion size; bone marrow transplantation experiments suggest that the increased lesion size might be caused by ACAT1 deficiency in macrophages ...[more]