Ontology highlight
ABSTRACT:
SUBMITTER: Kusters R
PROVIDER: S-EPMC3882470 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Kusters Remy R Kapitein Lukas C LC Hoogenraad Casper C CC Storm Cornelis C
Biophysical journal 20131201 12
Dendritic spines are the primary postsynaptic sites of excitatory neurotransmission in the brain. They exhibit a remarkable morphological variety, ranging from thin protrusions, to stubby shapes, to bulbous mushroom shapes. The remodeling of spines is thought to regulate the strength of the synaptic connection, which depends vitally on the number and the spatial distribution of AMPA-type glutamate receptors (AMPARs). We present numerical and analytical analyses demonstrating that this shape stro ...[more]