Ontology highlight
ABSTRACT:
SUBMITTER: Sarma BK
PROVIDER: S-EPMC3882750 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20110905 38
The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standard peptoid sub-monomer chemistry. Structural studies reveal that the main chain amide bond in these molecules predominantly adopts a trans conformation. A high-quality one bead one compound library of tetramers was made by split and pool synthesis and we found that the identity of the molecule on a sing ...[more]