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Plakinamine M, a steroidal alkaloid from the marine sponge Corticium sp.


ABSTRACT: By means of bioassay-guided fractionation, a new steroidal alkaloid, plakinamine M (1), and the known compound, plakinamine L (2), with a unique acyclic side chain, were isolated from the marine sponge Corticium sp. collected from New Britain, Papua New Guinea. The structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The two compounds showed inhibition of Mycobacterium tuberculosis with MIC values of 15.8 and 3.6 ?g/mL, respectively.

SUBMITTER: Lu Z 

PROVIDER: S-EPMC3883566 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Plakinamine M, a steroidal alkaloid from the marine sponge Corticium sp.

Lu Zhenyu Z   Koch Michael M   Harper Mary Kay MK   Matainaho Teatulohi K TK   Barrows Louis R LR   Van Wagoner Ryan M RM   Ireland Chris M CM  

Journal of natural products 20131106 11


By means of bioassay-guided fractionation, a new steroidal alkaloid, plakinamine M (1), and the known compound, plakinamine L (2), with a unique acyclic side chain, were isolated from the marine sponge Corticium sp. collected from New Britain, Papua New Guinea. The structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The two compounds showed inhibition of Mycobacterium tuberculosis with MIC values of 15.8 and 3.6 μg/mL, respectively. ...[more]

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