Placental HTR2A methylation is associated with infant neurobehavioral outcomes.
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ABSTRACT:
SUBMITTER: Paquette AG
PROVIDER: S-EPMC3883782 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Placental HTR2A methylation is associated with infant neurobehavioral outcomes.
Paquette Alison G AG Lesseur Corina C Armstrong David A DA Koestler Devin C DC Appleton Allison A AA Lester Barry M BM Marsit Carmen J CJ
Epigenetics 20130619 8
The serotonin receptor, HTR2A, exhibits placental expression and function and can be controlled through DNA methylation. The relationship between methylation of HTR2A in the placenta and neurodevelopmental outcomes, evaluated using the NICU Network Neurobehavioral Scales (NNNS), was assessed in newborn infants (n = 444). HTR2A methylation was significantly higher in males and marginally higher in infants whose mothers reported tobacco use during pregnancy. Controlling for confounding variables, ...[more]
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