Ontology highlight
ABSTRACT:
SUBMITTER: Tseng AM
PROVIDER: S-EPMC6399548 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Tseng Alexander M AM Mahnke Amanda H AH Wells Alan B AB Salem Nihal A NA Allan Andrea M AM Roberts Victoria Hj VH Newman Natali N Walter Nicole Ar NA Kroenke Christopher D CD Grant Kathleen A KA Akison Lisa K LK Moritz Karen M KM Chambers Christina D CD Miranda Rajesh C RC
Life science alliance 20190304 2
Prenatal alcohol exposure (PAE), like other pregnancy complications, can result in placental insufficiency and fetal growth restriction, although the linking causal mechanisms are unclear. We previously identified 11 gestationally elevated maternal circulating miRNAs (<sub>HEa</sub>miRNAs) that predicted infant growth deficits following PAE. Here, we investigated whether these <sub>HEa</sub>miRNAs contribute to the pathology of PAE, by inhibiting trophoblast epithelial-mesenchymal transition (EM ...[more]