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Oxime cross-linked injectable hydrogels for catheter delivery.


ABSTRACT: Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross-linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue.

SUBMITTER: Grover GN 

PROVIDER: S-EPMC3884068 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Oxime cross-linked injectable hydrogels for catheter delivery.

Grover Gregory N GN   Braden Rebecca L RL   Christman Karen L KL  

Advanced materials (Deerfield Beach, Fla.) 20130312 21


Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross-linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue. ...[more]

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