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Progenitor “Mycobacterium canettii” clone responsible for lymph node tuberculosis epidemic, Djibouti.

ABSTRACT: “Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.

SUBMITTER: Blouin Y 

PROVIDER: S-EPMC3884719 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Progenitor “Mycobacterium canettii” clone responsible for lymph node tuberculosis epidemic, Djibouti.

Blouin Yann Y   Cazajous Géraldine G   Dehan Céline C   Soler Charles C   Vong Rithy R   Hassan Mohamed Osman MO   Hauck Yolande Y   Boulais Christian C   Andriamanantena Dina D   Martinaud Christophe C   Martin Émilie É   Pourcel Christine C   Vergnaud Gilles G  

Emerging infectious diseases 20140101 1

“Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberc  ...[more]

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