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Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex.

ABSTRACT: Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g., Mycobacterium orygis cannot be differentiated from Mycobacterium africanum).

SUBMITTER: Loiseau C

PROVIDER: S-EPMC6535525 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex.

Loiseau Chloé C Brites Daniela D Moser Irmgard I Coll Francesc F Pourcel Christine C Robbe-Austerman Suelee S Escuyer Vincent V Musser Kimberlee A KA Peacock Sharon J SJ Feuerriegel Silke S Kohl Thomas A TA Niemann Stefan S Gagneux Sebastien S Köser Claudio U CU

Antimicrobial agents and chemotherapy 20190524 6

Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limit ...[more]

PMID: 30962348

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