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Vanadium-catalyzed oxidative Strecker reaction: ?-C-H cyanation of para-methoxyphenyl (PMP)-protected primary amines.

ABSTRACT: We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the ?-C position bearing either an alkyl or an aromatic group. This method provides a direct access to ?-aminonitrile from amines with one-carbon extension.

SUBMITTER: Zhu C 

PROVIDER: S-EPMC3885172 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Vanadium-catalyzed oxidative Strecker reaction: α-C-H cyanation of <i>para</i>-methoxyphenyl (PMP)-protected primary amines.

Zhu Chen C   Xia Ji-Bao JB   Chen Chuo C  

Tetrahedron letters 20140101 1

We describe an oxidative Strecker reaction that allows for direct cyanation of <i>para</i>-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension. ...[more]

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