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Chiral ?-Iodoamines by Urea-Catalyzed Iodocyclization of Trichloroacetimidates.

ABSTRACT: Highly enantioselective vicinal iodoamination of olefins is accomplished through the iodocyclization of alkenyl trichloroacetimidates catalyzed by a new chiral Schiff-base urea derivative. The resulting products are converted readily to a variety of polyfunctional amine-containing chiral building blocks.

SUBMITTER: Brindle CS

PROVIDER: S-EPMC3885344 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Chiral β-Iodoamines by Urea-Catalyzed Iodocyclization of Trichloroacetimidates.

Brindle Cheyenne S CS Yeung Charles S CS Jacobsen Eric N EN

Chemical sciences journal 20130501 5

Highly enantioselective vicinal iodoamination of olefins is accomplished through the iodocyclization of alkenyl trichloroacetimidates catalyzed by a new chiral Schiff-base urea derivative. The resulting products are converted readily to a variety of polyfunctional amine-containing chiral building blocks. ...[more]

PMID: 24416631

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