Dataset Information

Milk consumption and cardiovascular risk factors in older Chinese: the Guangzhou Biobank Cohort Study.

ABSTRACT: Dairy products consumption is increasingly common globally. Most of the evidence concerning dairy products comes from observational studies in western populations which are inevitably open to confounding. To triangulate the evidence concerning dairy products, we examined the associations of whole cow's milk consumption with cardiovascular risk factors in a non-Western setting with a different pattern of milk consumption and cardiovascular diseases from Western populations.We used multivariable censored linear or logistic regression to examine cross-sectionally the adjusted associations of whole cow's milk consumption (none (n?=?14892), 1-3/week (n?=?2689) and 3+/week (n?=?2754)) with cardiovascular risk factors in Chinese (?50 years) in the Guangzhou Biobank Cohort Study.Whole cow's milk consumption was negatively associated with systolic blood pressure (3+/week compared to none -2.56 mmHg, 95% confidence interval (CI) -3.63 to -1.49), diastolic blood pressure (-1.32 mmHg, 95% CI -1.87 to -0.77) and triglycerides (-0.06 mmol/L, 95% CI -0.11 to -0.002), but was positively associated with HDL-cholesterol (0.02 mmol/L,95% CI 0.01 to 0.04) and fasting glucose (0.08 mmol/L, 95% CI 0.01 to 0.16) adjusted for age, sex, phase of study, socio-economic position, lifestyle (smoking, alcohol use and physical activity) and adiposity, but had no obvious association with LDL-cholesterol or the presence of diabetes.Whole cow's milk consumption had heterogeneous associations with cardiovascular risk factors. Higher whole cow's milk consumption was associated with lower levels of specific cardiovascular risk factors which might suggest risk factor specific biological pathways with different relations to blood pressure and lipids than glucose.

SUBMITTER: Sun Y

PROVIDER: S-EPMC3885601 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Milk consumption and cardiovascular risk factors in older Chinese: the Guangzhou Biobank Cohort Study.

Sun Yangbo Y Jiang Chaoqiang C Cheng Kar Keung KK Zhang Weisen W Leung Gabriel M GM Lam Tai Hing TH Schooling C Mary CM

PloS one 20140108 1

<h4>Background</h4>Dairy products consumption is increasingly common globally. Most of the evidence concerning dairy products comes from observational studies in western populations which are inevitably open to confounding. To triangulate the evidence concerning dairy products, we examined the associations of whole cow's milk consumption with cardiovascular risk factors in a non-Western setting with a different pattern of milk consumption and cardiovascular diseases from Western populations.<h4> ...[more]

PMID: 24416290

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Project description:BACKGROUND: In observational studies from western countries childhood emotional adversity is usually associated with adult cardiovascular disease. These findings are open to contextual biases making evidence from other settings valuable. We examined the association of a potential marker of childhood emotional adversity with cardiovascular disease risk factors in a developing country. METHODS: We used multivariable regression in cross-sectional analysis of older (≥50 years) men (n = 7,885) and women (n = 20,886) from the Guangzhou Biobank Cohort Study (2003-8) to examine the adjusted association of early life (<18 years) parental death (none, one or two deaths) with blood pressure, fasting glucose, LDL-cholesterol, HDL-cholesterol, triglycerides, body mass index (BMI), waist-hip ratio (WHR) and white blood cell count (WBC). We used seated height and delayed 10-word recall to assess content validity of parental death as a measure of childhood emotional adversity. We also examined whether associations varied by sex. RESULTS: Early life parental death was associated with shorter age- and sex-adjusted seated height. It was also associated with lower 10-word recall score adjusted for age, sex, socio-economic position, leg length and lifestyle. Similarly, adjusted early life parental death was not associated with blood pressure, fasting glucose, LDL-cholesterol or HDL-cholesterol but was associated with lower BMI (-0.40, 95% confidence interval (CI) -0.62 to -0.19 for 2 compared with no early life parental deaths) and triglycerides. Associations varied by sex for WHR and WBC. Among men only, early life parental death was associated with lower WHR (-0.008, 95% CI -0.015 to -0.001) and WBC (-0.35 10(9)/L, 95% CI -0.56 to -0.13). CONCLUSIONS: In a non-western population from a developing country, childhood emotional adversity was negatively associated with some cardiovascular risk factors, particularly among men. Our study suggests that some of the observed associations in western populations may be socially rather than biologically based or may be population specific.

Project description:BackgroundThe relationship between women's reproductive characteristics and stroke events is unclear. We aimed to investigate age at menarche, age at menopause and number of reproductive years in relation to fatal stroke occurrence in the Guangzhou Biobank Cohort Study.MethodsIn total, 16,504 postmenopausal women without stroke, heart disease or a cancer history at baseline were included and followed up for a median of 12.0 years. After review of available records, 222 stroke deaths were recorded. Cox proportional hazards regression was used to assess the associations between the risk of fatal stroke occurrence and age at menarche, age at menopause and number of reproductive years.ResultsIn the whole cohort, compared with those aged 15 years at menarche, an increased risk of fatal stroke among women at menarche showed respectively in those aged 12 years (aHR (adjusted hazard ratio) = 1.86, 95% confidence interval (CI) 0.96-3.60), aged 13 years (aHR = 1.69, 95% CI 0.98-2.92), aged 17 years (aHR = 1.83, 95% CI 1.10-3.05) and aged ≥ 18 years (aHR = 1.66, 95% CI 1.03-2.70), wherein the associations revealed an atypically U-shaped; similar U-shaped association to the cohort of postmenopausal women born before 1940 released a range of incremental risks of fatal stroke in women at menarche aged ≤ 12 years (aHR = 3.68, 95% CI 1.68-8.05), aged 13 years (aHR = 2.11, 95% CI 1.02-4.34), aged 14 years (aHR = 2.07, 95% CI 1.04), aged 17 years (aHR = 2.30, 95% CI 1.20-4.39) and aged 18 years (aHR = 2.50, 95% CI 1.37-4.57), respectively. Compared with menopausal women aged 51-52 years, those aged < 43 years at menopause had an increased risk for fatal stroke among postmenopausal women born in and after 1940 (aHR = 1.64, 95% CI 0.97-2.78) and postmenopausal women born before 1940 (aHR = 1.97, 95% CI 1.05-3.69). Additionally, compared with those with 32-34 reproductive years, women with ≤ 28 reproductive years had an increased risk for fatal stroke in the whole cohort (aHR = 1.91, 95% CI 1.28-2.86) and the cohort of postmenopausal women born before 1940 (aHR = 1.79, 95% CI 1.15-2.80).ConclusionsYounger and older age at menarche, younger age at menopause and fewer reproductive ages were related to an increased risk of fatal stroke in postmenopausal women.

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Dataset Information

Milk consumption and cardiovascular risk factors in older Chinese: the Guangzhou Biobank Cohort Study.

Publications

Milk consumption and cardiovascular risk factors in older Chinese: the Guangzhou Biobank Cohort Study.

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