Dataset Information

Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study.

ABSTRACT: Previous studies on Chinese showed mixed results describing the relationship between obesity and mortality. The optimum levels of body mass index (BMI) and waist circumference (WC) are inconsistent. In the Guangzhou Biobank Cohort Study, after excluding ever smokers and those with poor health, 19,405 Chinese (50+ years) recruited from 2003 to 2008 were followed-up until 2017. During an average follow-up of 11.5 (standard deviation?=?2.3) years, 1,757 deaths were recorded. All-cause mortality showed a J-shaped association with BMI, with the lowest mortality risks at 22.5?kg/m2 for both men and women. In those with BMI???22.5?kg/m2, an increase of 5?kg/m2 was associated with 29% higher all-cause mortality (hazard ratio (HR)?=?1.29, 95% confidence interval (CI) 1.15-1.46), 30% higher cancer mortality (1.30, 95% CI 1.08-1.57), and 37% higher cardiovascular disease (CVD) mortality (1.37, 95% CI 1.13-1.67) after adjustment for potential confounders. In this first cohort study in one of the most economically developed cities in China, the lowest all-cause mortality was observed for a BMI of 22.5?kg/m2 in all participants, and a WC of 78?cm in men and 72?cm in women.

SUBMITTER: Jiang CQ

PROVIDER: S-EPMC7002501 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study.

Jiang Chao Qiang CQ Xu Lin L Zhang Wei Sen WS Jin Ya Li YL Zhu Feng F Cheng Kar Keung KK Lam Tai Hing TH

Scientific reports 20200205 1

Previous studies on Chinese showed mixed results describing the relationship between obesity and mortality. The optimum levels of body mass index (BMI) and waist circumference (WC) are inconsistent. In the Guangzhou Biobank Cohort Study, after excluding ever smokers and those with poor health, 19,405 Chinese (50+ years) recruited from 2003 to 2008 were followed-up until 2017. During an average follow-up of 11.5 (standard deviation = 2.3) years, 1,757 deaths were recorded. All-cause mortality sho ...[more]

PMID: 32024868

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Project description:BackgroundPhysical activity (PA) is generally encouraged. Studies from developed countries in the West have shown that maintenance of adequate PA or increasing PA are associated with lower mortality risk. It is unclear whether these associations apply to an older Chinese population. Hence, we examined the changes in PA prospectively among a middle-aged and older Chinese population over an average of 4 years and explored their subsequent mortality risks.MethodsMetabolic equivalent scores of PA among participants in the Guangzhou Biobank Cohort Study were calculated. Participants were divided into 3 groups related to PA level, and changes in PA were classified into 9 categories. Information on vital status and causes of death from March 2008 to December 2012 (the first repeated examination) until December 31, 2017, was obtained via record linkage with the Death Registry.ResultsOf 18,104 participants aged 61.21 ± 6.85 years (mean ± SD), 1461 deaths occurred within 141,417 person-years. Compared to participants who maintained moderate PA, those who decreased PA from moderate or high levels to a low level had increased risks for all-cause mortality (hazard ratio (HR) = 1.47, 95% confidence interval (95%CI): 1.11-1.96). Participants who maintained a high level of PA (HR = 0.83, 95%CI: 0.70-0.98) or increased PA from low to high levels (HR = 0.71, 95%CI: 0.52-0.97) showed lower all-cause mortality risks. Those who maintained low PA levels showed a higher all-cause mortality risk, whereas those who increased their PA levels showed a non-significantly lower risk. Similar results were found for cardiovascular disease risk.ConclusionEven at an older age, maintaining a high PA level or increasing PA from low to high levels results in lower mortality risks, suggesting that substantial health benefits might be achieved by maintaining or increasing engagement in adequate levels of PA. The increased risk of maintaining a low PA level or decreasing PA to a low level warrants the attention of public health officials and clinicians.

Dataset Information

Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study.

Publications

Adiposity and mortality in older Chinese: an 11-year follow-up of the Guangzhou Biobank Cohort Study.

Similar Datasets

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