Ontology highlight
ABSTRACT:
SUBMITTER: Ouyang S
PROVIDER: S-EPMC3887347 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Ouyang Suidong S Hsuchou Hung H Kastin Abba J AJ Wang Yuping Y Yu Chuanhui C Pan Weihong W
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20130925 1
The blood-brain barrier (BBB) is a regulatory interface between the central nervous system and the rest of the body. However, BBB changes in obesity and metabolic syndrome have not been fully elucidated. We hypothesized that obesity reduces energy metabolism in the cerebral microvessels composing the BBB, reflected by downregulation of protein expression and function. We performed comparative proteomic analyses in enriched microvessels from the cerebral cortex of mice 2 months after ingestion of ...[more]