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The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-?-D-glucose-treated MDA-MB-231 breast cancer cells: molecular target on cancer metabolism.

ABSTRACT: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a polyphenolic compound isolated from Rhus chinensis Mill. PGG has been known to have anti-tumor, anti-angiogenic and anti-diabetic activities. The present study revealed another underlying molecular target of PGG in MDA-MB-231 breast cancer cells by using Illumina Human Ref-8 expression BeadChip assay. Through the Beadstudio v3 micro assay program to compare the identified genes expressed in PGG-treated MDA-MB-231 cells with untreated control, we found several unique genes that are closely associated with pyruvate metabolism, glycolysis/gluconeogenesis and tyrosine metabolism, including PC, ACSS2, ACACA, ACYP2, ALDH3B1, FBP1, PRMT2 and COMT. Consistent with microarray data, real-time RT-PCR confirmed the significant down-regulation of these genes at mRNA level in PGG-treated MDA-MB-231 cells. Our findings suggest the potential of PGG as anticancer agent for breast cancer cells by targeting cancer metabolism genes.

SUBMITTER: Yu WS 

PROVIDER: S-EPMC3887664 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: molecular target on cancer metabolism.

Yu Woo Sik WS   Jeong Soo-Jin SJ   Kim Ji-Hyun JH   Lee Hyo-Jung HJ   Song Hyo Sook HS   Kim Min-Seok MS   Ko Eunjung E   Lee Hyo-Jeong HJ   Khil Jae-Ho JH   Jang Hyeung-Jin HJ   Kim Young Chul YC   Bae Hyunsu H   Chen Chang Yan CY   Kim Sung-Hoon SH  

Molecules and cells 20110524 2

1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a polyphenolic compound isolated from Rhus chinensis Mill. PGG has been known to have anti-tumor, anti-angiogenic and anti-diabetic activities. The present study revealed another underlying molecular target of PGG in MDA-MB-231 breast cancer cells by using Illumina Human Ref-8 expression BeadChip assay. Through the Beadstudio v3 micro assay program to compare the identified genes expressed in PGG-treated MDA-MB-231 cells with untreated control, we  ...[more]

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