Ontology highlight
ABSTRACT:
SUBMITTER: Sokol CL
PROVIDER: S-EPMC3888112 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Sokol Caroline L CL Barton Gregory M GM Farr Andrew G AG Medzhitov Ruslan R
Nature immunology 20080301 3
Both metazoan parasites and simple protein allergens induce T helper type 2 (TH2) immune responses, but the mechanisms by which the innate immune system senses these stimuli are unknown. In addition, the cellular source of cytokines that control TH2 differentiation in vivo has not been defined. Here we showed that basophils were activated and recruited to the draining lymph nodes specifically in response to TH2-inducing allergen challenge. Furthermore, we demonstrate that the basophil was the ac ...[more]