Ontology highlight
ABSTRACT:
SUBMITTER: Gauvreau GM
PROVIDER: S-EPMC4253735 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Gauvreau G M GM Boulet L-P LP Cockcroft D W DW FitzGerald J M JM Mayers I I Carlsten C C Laviolette M M Killian K J KJ Davis B E BE Larché M M Kipling C C Dua B B Mosesova S S Putnam W W Zheng Y Y Scheerens H H McClintock D D Matthews J G JG O'Byrne P M PM
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20140101 1
<h4>Background</h4>The OX40/OX40L interaction contributes to an optimal T cell response following allergic stimuli and plays an important role in the maintenance and reactivation of memory T effector cells.<h4>Objective</h4>We tested whether treatment with an anti-OX40L monoclonal antibody (MAb) would inhibit allergen-induced responses in subjects with asthma.<h4>Methods</h4>Twenty-eight mild, atopic asthmatic subjects were recruited for a double-blind, randomized, placebo-controlled, parallel-g ...[more]