Ontology highlight
ABSTRACT:
SUBMITTER: Poirier JT
PROVIDER: S-EPMC3888137 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Journal of the National Cancer Institute 20130605 14
We assessed the efficacy of Seneca Valley virus (SVV-001), a neuroendocrine cancer-selective oncolytic picornavirus, in primary heterotransplant mouse models of small cell lung cancer (SCLC), including three lines each of classic and variant SCLC. Half-maximal effective concentrations for cell lines derived from three variant heterotransplants ranged from 1.6×10(-3) (95% confidence interval [CI] = 1×10(-3) to 2.5×10(-3)) to 3.9×10(-3) (95% CI = 2.8×10(-3) to 5.5×10(-3)). Sustained tumor growth i ...[more]