Ontology highlight
ABSTRACT:
SUBMITTER: Feng L
PROVIDER: S-EPMC3888515 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20120122 2
The ubiquitination cascade has a key role in the assembly of repair and signaling proteins at sites of double-strand DNA breaks. The E3 ubiquitin ligase RING finger protein 8 (RNF8) triggers the initial ubiquitination at double-strand DNA breaks, whereas sustained ubiquitination requires the downstream E3 ligase RING finger protein 168 (RNF168). It is not known whether RNF8 and RNF168 have discrete substrates and/or form different ubiquitin chains. Here we show that RNF168 acts with the ubiquiti ...[more]