Ontology highlight
ABSTRACT:
SUBMITTER: Ma C
PROVIDER: S-EPMC6110584 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ma Chengxian C Ha Kyungsoo K Kim Min-Su MS Noh Young-Woock YW Lin Han H Tang Lichun L Zhu Qing Q Zhang Dan D Chen Huan H Han Suxia S Zhang Pumin P
Cell cycle (Georgetown, Tex.) 20180718 9
Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). The choice between these two pathways is largely influenced by cell cycle phases. HDR can occur only in S/G2 when sister chromatid can provide homologous templates, whereas NHEJ can take place in all phases of the cell cycle except mitosis. Central to NHEJ repair is the Ku70/80 heterodimer which forms a ring structure that binds DSB ends and serves as ...[more]