Ontology highlight
ABSTRACT:
SUBMITTER: Dachsel JC
PROVIDER: S-EPMC3889543 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Dachsel Justus C JC Ngok Siu P SP Lewis-Tuffin Laura J LJ Kourtidis Antonis A Geyer Rory R Johnston Lauren L Feathers Ryan R Anastasiadis Panos Z PZ
Molecular and cellular biology 20131014 24
The role of RhoA in promoting directed cell migration has been complicated by studies showing that it is activated both in the front and the rear of migrating cells. We report here that the RhoA-specific guanine nucleotide exchange factor Syx is required for the polarity of actively migrating brain and breast tumor cells. This function of Syx is mediated by the selective activation of the RhoA downstream effector Dia1, the subsequent reorganization of microtubules, and the downregulation of foca ...[more]