Ontology highlight
ABSTRACT:
SUBMITTER: Ngok SP
PROVIDER: S-EPMC3585103 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Ngok Siu P SP Geyer Rory R Kourtidis Antonis A Storz Peter P Anastasiadis Panos Z PZ
The Journal of biological chemistry 20130118 9
Syx is a Rho-specific guanine nucleotide exchange factor (GEF) that localizes at cell-cell junctions and promotes junction stability by activating RhoA and the downstream effector Diaphanous homolog 1 (Dia1). Previously, we identified several molecules, including 14-3-3 proteins, as Syx-interacting partners. In the present study, we show that 14-3-3 isoforms interact with Syx at both its N- and C-terminal regions in a phosphorylation-dependent manner. We identify the protein kinase D-mediated ph ...[more]