Ontology highlight
ABSTRACT:
SUBMITTER: Brison J
PROVIDER: S-EPMC3889863 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Brison Jeremy J Robinson Michael A MA Benoit Danielle S W DS Muramoto Shin S Stayton Patrick S PS Castner David G DG
Analytical chemistry 20131105 22
In this study, a non-native chemical species, bromodeoxyuridine (BrdU), was imaged within single HeLa cells using time-of-flight secondary ion mass spectrometry (TOF-SIMS). z-corrected 3D images were reconstructed that accurately portray the distribution of intracellular BrdU as well as other intracellular structures. The BrdU was localized to the nucleus of cells, whereas structures composed of CxHyOz(-) species were located in bundles on the periphery of cells. The CxHyOz(-) subcellular featur ...[more]