Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.
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ABSTRACT:
SUBMITTER: Oelsner EC
PROVIDER: S-EPMC3890095 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.
Oelsner E C EC Pottinger T D TD Burkart K M KM Allison M M Buxbaum S G SG Hansel N N NN Kumar R R Larkin E K EK Lange L A LA Loehr L R LR London S J SJ O'Connor G T GT Papanicolaou G G Petrini M F MF Rabinowitz D D Raghavan S S Redline S S Thyagarajan B B Tracy R P RP Wilk J B JB White W B WB Rich S S SS Barr R G RG
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20130405 3
<h4>Context</h4>Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.<h4>Objective</h4>Test associations of endothelial biomarkers with FEV1 using instrumental variables.<h4>Methods</h4>Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.<h4>Results</h4>ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 ...[more]
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