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Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.

ABSTRACT: CONTEXT:Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. OBJECTIVE:Test associations of endothelial biomarkers with FEV1 using instrumental variables. METHODS:Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. RESULTS:ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (-22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative. CONCLUSION:Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

SUBMITTER: Oelsner EC 

PROVIDER: S-EPMC3890095 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.

Oelsner E C EC   Pottinger T D TD   Burkart K M KM   Allison M M   Buxbaum S G SG   Hansel N N NN   Kumar R R   Larkin E K EK   Lange L A LA   Loehr L R LR   London S J SJ   O'Connor G T GT   Papanicolaou G G   Petrini M F MF   Rabinowitz D D   Raghavan S S   Redline S S   Thyagarajan B B   Tracy R P RP   Wilk J B JB   White W B WB   Rich S S SS   Barr R G RG  

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20130405 3

<h4>Context</h4>Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.<h4>Objective</h4>Test associations of endothelial biomarkers with FEV1 using instrumental variables.<h4>Methods</h4>Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.<h4>Results</h4>ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34  ...[more]

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