Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC3890438 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Fu Yuan Y Ramisetty Sreenivasa Rao SR Hussain Nejmun N Baranger Anne M AM
Chembiochem : a European journal of chemical biology 20111122 1
Muscleblind-like proteins (MBNL) are RNA-binding proteins that bind to the poly(CUG) and poly(CCUG) sequences that are the causative agents of myotonic dystrophy. It has been suggested that as a result of binding to the repeating RNA sequences, MBNL1 is abnormally expressed and translocated, which leads to many of the misregulated events in myotonic dystrophy. In this work, steady-state fluorescence quenching experiments suggest that MBNL1 alters the structure of helical RNA targets upon binding ...[more]