Ontology highlight
ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC3890457 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Cao Huibi H Machuca Tiago N TN Yeung Jonathan C JC Wu Jing J Du Kai K Duan Cathleen C Hashimoto Kohei K Linacre Virginia V Coates Allan L AL Leung Kitty K Wang Jian J Yeger Herman H Cutz Ernest E Liu Mingyao M Keshavjee Shaf S Hu Jim J
Molecular therapy. Nucleic acids 20131008
Airway gene delivery is a promising strategy to treat patients with life-threatening lung diseases such as cystic fibrosis (CF). However, this strategy has to be evaluated in large animal preclinical studies in order to translate it to human applications. Because of anatomic and physiological similarities between the human and pig lungs, we utilized pig as a large animal model to examine the safety and efficiency of airway gene delivery with helper-dependent adenoviral vectors. Helper-dependent ...[more]