Ontology highlight
ABSTRACT:
SUBMITTER: Kamoun M
PROVIDER: S-EPMC3891829 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Kamoun Malek M Filali Mohammed M Murray Michael V MV Awasthi Sita S Wadzinski Brian E BE
Biochemical and biophysical research communications 20130921 2
Protein phosphorylation and dephosphorylation are both important for multiple steps in the splicing pathway. Members of the PP1 and PP2A subfamilies of phospho-serine/threonine phosphatases play essential but redundant roles in the second step of the splicing reaction. PP6, a member of the PP2A subfamily, is the mammalian homolog of yeast Sit4p and ppe1, which are involved in cell cycle regulation; however, the involvement of PP6 in the splicing pathway remains unclear. Here we show that PP2A fa ...[more]