Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation.
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ABSTRACT:
SUBMITTER: Bailey KA
PROVIDER: S-EPMC3892431 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
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Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation.
Bailey Kathryn A KA Wu Michael C MC Ward William O WO Smeester Lisa L Rager Julia E JE García-Vargas Gonzalo G Del Razo Luz-Maria LM Drobná Zuzana Z Stýblo Miroslav M Fry Rebecca C RC
Journal of biochemical and molecular toxicology 20130111 2
Biotransformation of inorganic arsenic (iAs) is one of the factors that determines the character and magnitude of the diverse detrimental health effects associated with chronic iAs exposure, but it is unknown how iAs biotransformation may impact the epigenome. Here, we integrated analyses of genome-wide, gene-specific promoter DNA methylation levels of peripheral blood leukocytes with urinary arsenical concentrations of subjects from a region of Mexico with high levels of iAs in drinking water. ...[more]
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