Ontology highlight
ABSTRACT:
SUBMITTER: Park JS
PROVIDER: S-EPMC3892952 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Park Joo-Seop JS Ma Wenxiu W O'Brien Lori L LL Chung Eunah E Guo Jin-Jin JJ Cheng Jr-Gang JG Valerius M Todd MT McMahon Jill A JA Wong Wing Hung WH McMahon Andrew P AP
Developmental cell 20120816 3
A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin immunoprecipitation and transcriptional profiling identified direct target genes shared by each pathway within nephron progenitors. Wnt4 and Fgf8 are essential for progenitor commitment; cis-regulatory modules flanking each gene are cobound by Six2 and β-catenin and are dependent on conserved Lef/Tcf binding sites for activity. In ...[more]