Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC7032615 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cell reports 20170101 4
The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors. Six2-positive (Six2<sup>+</sup>) progenitors are rapidly recruited and assigned, and their descendants are allocated successively to regions of the heart from the right ventricle (RV) to the pulmonary trunk. Global ablation of Six2<sup>+</sup> progenitors resulted in RV hypoplasia and pulmonary atresia. An early stage- ...[more]