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Synthesis of ?-cyclodextrin containing copolymer via "click" chemistry and its self-assembly in the presence of guest compounds.


ABSTRACT: We report the synthesis of a hydrophilic copolymer with one polyethylene glycol (PEG) block and one ?-cyclodextrin (?-CD) containing block by a "click" reaction between azido-substituted ?-CD and propargyl flanking copolymer. (1)H NMR study suggested a highly efficient conjugation of ?-CD units by this approach. The obtained copolymer was used as a host macromolecule to construct assemblies in the presence of hydrophobic guests. For assemblies containing a hydrophobic polymer, their size can be simply adjusted by simply changing the content of hydrophobic component. By serving as a guest molecule, hydrophobic drugs can also be loaded accompanying the formation of nanoparticles, and the drug payload is releasable. Therefore, the copolymer synthesized herein can be employed as a carrier for drug delivery.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC3893059 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Synthesis of β-cyclodextrin containing copolymer via "click" chemistry and its self-assembly in the presence of guest compounds.

Zhang Jianxiang J   Ellsworth Kristin K   Ma Peter X PX  

Macromolecular rapid communications 20120209 8


We report the synthesis of a hydrophilic copolymer with one polyethylene glycol (PEG) block and one β-cyclodextrin (β-CD) containing block by a "click" reaction between azido-substituted β-CD and propargyl flanking copolymer. (1)H NMR study suggested a highly efficient conjugation of β-CD units by this approach. The obtained copolymer was used as a host macromolecule to construct assemblies in the presence of hydrophobic guests. For assemblies containing a hydrophobic polymer, their size can be  ...[more]

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