Ontology highlight
ABSTRACT:
SUBMITTER: Blum JM
PROVIDER: S-EPMC3893104 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Blum Jordan M JM Añó Leonor L Li Zhizhong Z Van Mater David D Bennett Brian D BD Sachdeva Mohit M Lagutina Irina I Zhang Minsi M Mito Jeffrey K JK Dodd Leslie G LG Cardona Diana M DM Dodd Rebecca D RD Williams Nerissa N Ma Yan Y Lepper Christoph C Linardic Corinne M CM Mukherjee Sayan S Grosveld Gerard C GC Fan Chen-Ming CM Kirsch David G DG
Cell reports 20131114 4
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, whereas undifferentiated pleomorphic sarcoma (UPS) is one of the most common soft tissue sarcomas diagnosed in adults. To investigate the myogenic cell(s) of origin of these sarcomas, we used Pax7-CreER and MyoD-CreER mice to transform Pax7(+) and MyoD(+) myogenic progenitors by expressing oncogenic Kras(G12D) and deleting Trp53 in vivo. Pax7-CreER mice developed RMS and UPS, whereas MyoD-CreER mice developed UPS. Using g ...[more]