Ontology highlight
ABSTRACT:
SUBMITTER: Morena D
PROVIDER: S-EPMC4811764 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Morena Deborah D Maestro Nicola N Bersani Francesca F Forni Paolo Emanuele PE Lingua Marcello Francesco MF Foglizzo Valentina V Šćepanović Petar P Miretti Silvia S Morotti Alessandro A Shern Jack F JF Khan Javed J Ala Ugo U Provero Paolo P Sala Valentina V Crepaldi Tiziana T Gasparini Patrizia P Casanova Michela M Ferrari Andrea A Sozzi Gabriella G Chiarle Roberto R Ponzetto Carola C Taulli Riccardo R
eLife 20160317
Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the niche microenvironment. In a Pax7 wild type background, HGF stimulation mainly causes ERMS that originate from satellite cells following a process of multistep progression. Conversely, in a Pax7 null genotype ERMS incidence drops, while UPS be ...[more]