Ontology highlight
ABSTRACT:
SUBMITTER: McBrian MA
PROVIDER: S-EPMC3893119 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
McBrian Matthew A MA Behbahan Iman Saramipoor IS Ferrari Roberto R Su Trent T Huang Ta-Wei TW Li Kunwu K Hong Candice S CS Christofk Heather R HR Vogelauer Maria M Seligson David B DB Kurdistani Siavash K SK
Molecular cell 20121129 2
Differences in global levels of histone acetylation occur in normal and cancer cells, although the reason why cells regulate these levels has been unclear. Here we demonstrate a role for histone acetylation in regulating intracellular pH (pH(i)). As pH(i) decreases, histones are globally deacetylated by histone deacetylases (HDACs), and the released acetate anions are coexported with protons out of the cell by monocarboxylate transporters (MCTs), preventing further reductions in pH(i). Conversel ...[more]