Ontology highlight
ABSTRACT:
SUBMITTER: Raja DA
PROVIDER: S-EPMC6945066 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Raja Desingu Ayyappa DA Gotherwal Vishvabandhu V Burse Shaunak A SA Subramaniam Yogaspoorthi J YJ Sultan Farina F Vats Archana A Gautam Hemlata H Sharma Babita B Sharma Sachin S Singh Archana A Sivasubbu Sridhar S Gokhale Rajesh S RS Natarajan Vivek T VT
EMBO reports 20191111 1
Tanning response and melanocyte differentiation are mediated by the central transcription factor MITF. This involves the rapid and selective induction of melanocyte maturation genes, while concomitantly the expression of other effector genes is maintained. In this study, using cell-based and zebrafish model systems, we report on a pH-mediated feed-forward mechanism of epigenetic regulation that enables selective amplification of the melanocyte maturation program. We demonstrate that MITF activat ...[more]