Differential effects of PDCD4 depletion on protein synthesis in myoblast and myotubes.
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ABSTRACT:
SUBMITTER: Kakade D
PROVIDER: S-EPMC3893489 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Differential effects of PDCD4 depletion on protein synthesis in myoblast and myotubes.
Kakade Dhanshri D Islam Nushaba N Maeda Naomi N Adegoke Olasunkanmi A J OA
BMC cell biology 20140109
<h4>Background</h4>Reduced muscle mass is a hallmark of metabolic diseases like diabetes and cancer. The mammalian (mechanistic) target of rapamycin complex 1/S6 kinase 1 (mTORC1/S6K1) pathway is critical to the regulation of muscle protein synthesis and mass but its mechanism of action is not completely understood.<h4>Results</h4>Using L6 myotubes, we characterized the regulation of programmed cell death 4 (PDCD4), a recently described substrate of S6K1. The abundance, but not Ser67 phosphoryla ...[more]
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