Ontology highlight
ABSTRACT:
SUBMITTER: Zhou P
PROVIDER: S-EPMC3893658 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Zhou Peng P Ross Ruth A RA Pywell Cameron M CM Liangpunsakul Suthat S Duffield Giles E GE
Scientific reports 20140116
To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed over 4-weeks that resulted in steatosis. Here we show time-of-day specific changes in expression of clock genes and clock-controlled genes, including those associated with lipid and bile acid regulation. Such changes were not observed following a 1-week alcohol treatment with no hepatic lipid accumulation. Real-time bioluminescence reporting ...[more]