Ontology highlight
ABSTRACT:
SUBMITTER: Ramond E
PROVIDER: S-EPMC3894225 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Ramond Elodie E Gesbert Gael G Rigard Mélanie M Dairou Julien J Dupuis Marion M Dubail Iharilalao I Meibom Karin K Henry Thomas T Barel Monique M Charbit Alain A
PLoS pathogens 20140116 1
Intracellular bacterial pathogens have developed a variety of strategies to avoid degradation by the host innate immune defense mechanisms triggered upon phagocytocis. Upon infection of mammalian host cells, the intracellular pathogen Francisella replicates exclusively in the cytosolic compartment. Hence, its ability to escape rapidly from the phagosomal compartment is critical for its pathogenicity. Here, we show for the first time that a glutamate transporter of Francisella (here designated Ga ...[more]