Ontology highlight
ABSTRACT:
SUBMITTER: Ramond E
PROVIDER: S-EPMC4390266 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Ramond Elodie E Gesbert Gael G Guerrera Ida Chiara IC Chhuon Cerina C Dupuis Marion M Rigard Mélanie M Henry Thomas T Barel Monique M Charbit Alain A
Molecular & cellular proteomics : MCP 20150123 4
Upon entry into mammalian host cells, the pathogenic bacterium Francisella must import host cell arginine to multiply actively in the host cytoplasm. We identified and functionally characterized an arginine transporter (hereafter designated ArgP) whose inactivation considerably delayed bacterial phagosomal escape and intracellular multiplication. Intramacrophagic growth of the ΔargP mutant was fully restored upon supplementation of the growth medium with excess arginine, in both F. tularensis su ...[more]